Cytology & Cytogenetics

Chromosomal Numerical Aberration and It’s Genetical Effect

Kazal MahmudMay 12, 2025November 22, 202574 mins

Definition:Chromosomal numerical aberration refers to a change in the number of chromosomes in a cell. Normally, human cells have 46 chromosomes (23 pairs), but numerical aberrations involve either a gain or loss of chromosomes. This can lead to developmental disorders, genetic syndromes, or diseases such as cancer. Categories of Numerical Chromosomal Aberrations: Polyploidy: Polyploidy involves…

Chromosomal Structural Aberrations and It’s Genetical Effects

Kazal MahmudMay 12, 2025November 22, 202574 mins

Chromosomal Structural Aberrations are changes in the physical structure of chromosomes. These changes can affect gene expression and function, often leading to genetic disorders or abnormalities. Structural aberrations are categorized based on the type of chromosomal change involved. 1. Deletion 2. Duplication 3. Inversion 4. Translocation 5. Ring Chromosome 6. Isochromosome